HitPredict

Interactor 1: TOM70 (O94826)
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)
Gene: TOMM70

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34502139
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005739 - mitochondrion GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 608 Hs			1 724
+	Hs
		297024 TOM70_HUMAN (1-608): 1.09e-91: 296: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431797 IFT88_HUMAN (3-608): 1.78e-57: 209: 13.07		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438533 RPAP3_HUMAN (214-600): 9.89e-20: 95.4: 16.46		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		174561 OGT1_HUMAN (44-274): 2.25e-15: 82: 12.93		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432268 RPAP3_HUMAN (214-600): 9.89e-20: 95.4: 16.46		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438201 TOM34_HUMAN (288-555): 2.48e-14: 76.1: 11.96		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431774 SPAG1_HUMAN (483-608): 6.47e-16: 83.6: 12.70		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		174556 OGT1_HUMAN (44-274): 2.25e-15: 82: 12.93		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431886 TOM34_HUMAN (288-555): 2.48e-14: 76.1: 11.96		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Dm
		365476 Q9VEV3_DROME (112-222): 2.2e-15: 78.6: 40.54		HSP83_DROME (10-724): 0: 1057: 78.46
+	Sc
		365568 TOM70_YEAST (54-608): 1.02e-53: 195: 21.66		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		422983 TOM70_YEAST (54-608): 1.02e-53: 195: 21.66		HSC82_YEAST (13-724): 0: 922: 60.22
+	At
		878278 HSOP2_ARATH (76-404): 1.87e-15: 81.6: 16.52		HS902_ARATH (10-724): 0: 1003: 66.85
+	At
		137805 OE64C_ARATH (280-412): 5.62e-14: 76.9: 24.81		HS904_ARATH (10-724): 0: 1007: 66.85
+	At
		878283 OE64C_ARATH (280-412): 5.62e-14: 76.9: 24.81		HS902_ARATH (10-724): 0: 1003: 66.85
+	At
		646594 OE64C_ARATH (280-412): 5.62e-14: 76.9: 24.81		HS901_ARATH (10-724): 0: 999: 67.97
+	Sp
		784798 STI1_SCHPO (64-436): 4.38e-17: 87: 14.47		HSP90_SCHPO (10-724): 0: 929: 62.48
+	Hs
		174598 OGT1_HUMAN (44-274): 2.25e-15: 82: 12.93		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Zm
		33277 A0A1D6L1L3_MAIZE (121-217): 3.72e-15: 80.9: 42.27		A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66
+	Hs
		1162526 RPAP3_HUMAN (214-600): 9.89e-20: 95.4: 16.46		Q6PK50_HUMAN (1-350): 0: 618: 99.71