HitPredict

Interactor 1: IPO13 (O94829)
Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)
Gene: IPO13

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	21139563, 17828378, 23435562
Identification Methods	pull down, affinity chromatography technology, competition binding, thermal shift binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBN_N~Ras, Importin_rep~Ras, Importin_rep_3~Ras, Ras~Xpo1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 963 Hs			1 216
+	Hs
		162599 XPO1_HUMAN (10-963): 6.36e-159: 497: 15.02		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784987 MOS14_ARATH (23-952): 2.96e-130: 418: 19.73		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Sc
		675912 XPO1_YEAST (20-963): 2.68e-127: 413: 14.92		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sc
		697582 KA122_YEAST (22-939): 9.81e-127: 412: 14.83		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Dm
		1373317 Q9VRV8_DROME (16-874): 3.57e-117: 381: 11.01		RANL_DROME (1-210): 2.56e-93: 273: 60.48
+	Sc
		697583 KA122_YEAST (22-939): 9.81e-127: 412: 14.83		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		919198 TNPO1_HUMAN (34-874): 6.73e-121: 391: 13.23		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		155560 TNPO2_HUMAN (34-874): 3.13e-120: 390: 13.27		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784988 TNPO1_ARATH (10-909): 2.85e-103: 344: 10.75		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Hs
		207921 XPOT_HUMAN (27-952): 7.32e-110: 364: 12.39		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919273 XPO5_HUMAN (24-642): 2.94e-108: 364: 15.09		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		914368 XPO5_HUMAN (24-642): 2.94e-108: 364: 15.09		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Sp
		292805 XPOT_SCHPO (21-952): 1.95e-93: 319: 12.69		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	Sc
		698996 MTR10_YEAST (20-948): 9.91e-95: 323: 17.44		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		919228 XPO6_HUMAN (19-918): 2.44e-97: 333: 12.55		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		699022 MTR10_YEAST (20-948): 9.91e-95: 323: 17.44		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		312234 IPO7_HUMAN (28-883): 1.32e-92: 318: 11.21		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		127238 IPO5_HUMAN (29-901): 7.06e-91: 314: 11.67		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00