HitPredict

Interactor 1: RHBT1 (O94844)
Rho-related BTB domain-containing protein 1
Gene: RHOBTB1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	26100637, 35563538, 21145461, 18835386, 23040068, 30896450, 31431478, 33961781
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 696 Hs			1 768
+	Hs
		1042471 RHBT2_HUMAN (1-690): 2.28e-168: 502: 67.94		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		893985 CDC42_HUMAN (12-218): 1.55e-89: 279: 37.14		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		301202 RHBT3_HUMAN (41-670): 1.92e-77: 261: 20.37		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042716 IBTK_HUMAN (208-637): 7.17e-71: 253: 14.77		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1169620 IBTK_MOUSE (208-664): 4.5e-71: 253: 15.42		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Hs
		214258 SPOP_HUMAN (300-648): 8.45e-74: 244: 15.32		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		925262 RAC1_HUMAN (12-219): 7.28e-73: 235: 35.55		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042510 RAB1B_HUMAN (1-249): 4.91e-69: 226: 18.25		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		297660 RHBT1_HUMAN (1-696): 0: 541: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1274039 RHBT2_HUMAN (1-690): 2.28e-168: 502: 67.94		CUL5_HUMAN (25-768): 0: 597: 23.77
+	At
		1226186 BPM1_ARATH (349-687): 2.79e-76: 252: 13.19		CUL3A_ARATH (9-768): 0: 842: 51.45
+	At
		1341268 BPM2_ARATH (290-687): 3.87e-76: 252: 13.00		CUL3A_ARATH (9-768): 0: 842: 51.45
+	At
		186853 BPM3_ARATH (301-668): 1.61e-72: 242: 14.00		CUL3A_ARATH (9-768): 0: 842: 51.45
+	At
		1226178 BPM1_ARATH (349-687): 2.79e-76: 252: 13.19		CUL3B_ARATH (9-768): 0: 826: 50.92
+	Hs
		893986 CDC42_HUMAN (12-218): 1.55e-89: 279: 37.14		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	At
		186839 BPM3_ARATH (301-668): 1.61e-72: 242: 14.00		CUL3B_ARATH (9-768): 0: 826: 50.92
+	Hs
		214259 SPOP_HUMAN (300-648): 8.45e-74: 244: 15.32		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043210 RAB1B_HUMAN (1-249): 4.91e-69: 226: 18.25		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		893984 CDC42_HUMAN (12-218): 1.55e-89: 279: 37.14		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		545362 RAC2_HUMAN (12-219): 3.63e-71: 231: 36.97		CUL1_HUMAN (18-768): 0: 707: 30.57