HitPredict

Interactor 1: FARP2 (O94887)
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
Gene: FARP2

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016601 - Rac protein signal transduction GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 189
+	Hs
		299225 FARP2_HUMAN (1-1054): 0: 847: 100.00		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		349026 FARP1_HUMAN (1-1039): 0: 737: 52.90		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070476 FARP1_HUMAN (1-1039): 0: 737: 52.90		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		350721 FARP1_HUMAN (1-1039): 0: 737: 52.90		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349662 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349088 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348937 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		349644 E41L1_HUMAN (4-539): 4.5e-116: 381: 27.89		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		350075 FGD1_HUMAN (363-1037): 9.47e-125: 406: 22.15		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		348485 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		348923 E41L1_HUMAN (4-539): 4.5e-116: 381: 27.89		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070407 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		505636 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		350574 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349830 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		895282 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		350550 E41L1_HUMAN (4-539): 4.5e-116: 381: 27.89		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		505601 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		914374 E41L5_HUMAN (7-632): 2.56e-119: 385: 22.74		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		505614 EPB41_HUMAN (3-548): 2.87e-117: 383: 28.10		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88