HitPredict

Interactor 1: FARP2 (O94887)
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
Gene: FARP2

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase, C1_1~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1054 Hs			1 596
+	Hs
		299257 FARP2_HUMAN (1-1054): 0: 847: 100.00		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		983921 E41LB_HUMAN (33-592): 6.76e-113: 373: 24.25		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Dm
		49535 A0T1Z5_DROME (41-503): 4.45e-105: 348: 30.11		APKC_DROME (1-596): 0: 637: 65.67
+	Hs
		547019 EZRI_HUMAN (40-577): 2e-94: 314: 17.79		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		640215 PTN3_HUMAN (25-508): 1.77e-100: 339: 25.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		640223 PTN3_HUMAN (25-508): 1.77e-100: 339: 25.00		KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47
+	Hs
		566453 FGD4_HUMAN (342-1046): 2.76e-105: 348: 21.18		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Hs
		546921 EZRI_HUMAN (40-577): 2e-94: 314: 17.79		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37