HitPredict

Interactor 1: ERLN2 (O94905)
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)
Gene: ERLIN2

Interactor 2: HMDH (P04035)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Gene: HMGCR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	21343306, 17502376
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 339 Hs			1 888
+	Hs
		167786 ERLN2_HUMAN (1-339): 5.38e-116: 341: 100.00		NPC1_HUMAN (51-378): 1.22e-69: 253: 15.04
+	Hs
		299884 ERLN2_HUMAN (1-339): 5.38e-116: 341: 100.00		SCAP_HUMAN (53-253): 6.21e-48: 187: 22.43
+	Hs
		646185 STOM_HUMAN (3-254): 1.4e-70: 223: 16.34		PTC1_HUMAN (36-420): 2.33e-80: 286: 10.25
+	Hs
		167843 STOM_HUMAN (3-254): 1.4e-70: 223: 16.34		NPC1_HUMAN (51-378): 1.22e-69: 253: 15.04