HitPredict

Interactor 1: ERLN2 (O94905)
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)
Gene: ERLIN2

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	22119785, 21343306, 17502376, 24217618
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032991 - protein-containing complex and 1 others more... GO:0036503 - ERAD pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 339 Hs			1 643
+	Hs
		266273 ERLN1_HUMAN (20-333): 1.91e-100: 301: 78.03		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		299937 ERLN2_HUMAN (1-339): 5.38e-116: 341: 100.00		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Hs
		266188 ERLN1_HUMAN (20-333): 1.91e-100: 301: 78.03		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Hs
		299956 ERLN2_HUMAN (1-339): 5.38e-116: 341: 100.00		RN139_HUMAN (84-407): 7.91e-67: 232: 17.52
+	Hs
		266213 ERLN1_HUMAN (20-333): 1.91e-100: 301: 78.03		RN139_HUMAN (84-407): 7.91e-67: 232: 17.52
+	Hs
		610233 STOM_HUMAN (3-254): 1.4e-70: 223: 16.34		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37
+	Hs
		610527 STML2_HUMAN (20-319): 7.67e-59: 195: 14.24		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37