HitPredict

Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	29467282, 35013218, 36424410, 17314511, 21150319, 17353931
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 941 Hs			1 454
+	Hs
		300027 PRP6_HUMAN (1-941): 0: 610: 100.00		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		347832 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346795 RRP5_HUMAN (474-761): 1.34e-26: 120: 14.09		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347202 PRP39_HUMAN (425-927): 1.16e-23: 109: 15.92		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347086 CTR9_HUMAN (126-536): 3.3e-16: 85.7: 10.12		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347956 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		174528 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		379835 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379408 RRP5_HUMAN (474-761): 1.34e-26: 120: 14.09		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379565 PRP39_HUMAN (425-927): 1.16e-23: 109: 15.92		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Dm
		1178774 Q7K0X3_DROME (381-940): 1.55e-34: 145: 10.65		MYC_DROME (210-454): 3.25e-30: 126: 26.74
+	Mm
		1208456 OGT1_MOUSE (120-352): 4.66e-10: 65.7: 11.39		MLXPL_MOUSE (70-447): 2.06e-31: 129: 14.14