HitPredict

Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 941 Hs			1 526
+	Hs
		300218 PRP6_HUMAN (1-941): 0: 610: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		300118 PRP6_HUMAN (1-941): 0: 610: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		300288 PRP6_HUMAN (1-941): 0: 610: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Sc
		376625 PRP6_YEAST (4-924): 7.58e-80: 280: 21.50		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49
+	Hs
		1318165 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Zm
		7762 K7VP89_MAIZE (532-936): 1.55e-40: 162: 13.86		A0A1D6EIJ4_MAIZE (166-376): 1.49e-30: 126: 20.72
+	Sc
		865193 CLF1_YEAST (444-939): 6.13e-37: 150: 13.17		CUS2_YEAST (270-404): 1.07e-33: 131: 23.57
+	Hs
		726887 CTR9_HUMAN (126-536): 3.3e-16: 85.7: 10.12		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		1271196 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		175082 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		727046 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		174674 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Mm
		1142800 SYF1_MOUSE (109-527): 1.91e-12: 73.4: 13.33		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		1336499 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		174812 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Mm
		665754 CTR9_MOUSE (126-536): 5.01e-16: 85.3: 10.12		PABP1_MOUSE (184-382): 3.6e-12: 70.8: 12.44
+	Sc
		376611 CYC8_YEAST (641-915): 1.29e-13: 77.2: 17.12		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49
+	Hs
		174849 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Sc
		376930 RRP5_YEAST (276-524): 4.45e-12: 72.5: 17.28		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49
+	Hs
		174583 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44