Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 27173435, 28515276, 34079125, 35271311, 10788320, 35235311, 37071682, 16723661
Identification Methods affinity chromatography technology, proximity labelling technology, pull down, cross-linking study, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PROCN~PRP1_N
Common GO terms GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
and 8 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 941
Hs

1 2335
+ Hs
+ Hs
+ At
+ At
+ Dm
+ Dm
+ Sp
+ Sc
+ Sc

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Last updated: 15 Jul 2024