HitPredict

Interactor 1: RNF37 (O94941)
RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)
Gene: UBOX5

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	11435423, 19549727
Identification Methods	pull down, two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	U-box~UQ_con, UQ_con~zf-RING_5
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 541 Hs			1 147
+	Hs
		301058 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		301042 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		301050 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		301056 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		301043 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04