HitPredict

Interactor 1: RNF37 (O94941)
RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)
Gene: UBOX5

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	19549727
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	U-box~UQ_con, UQ_con~zf-RING_5
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding GO:0034450 - ubiquitin-ubiquitin ligase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 541 Hs			1 200
+	Hs
		301042 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		301058 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72
+	Hs
		301050 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		301047 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		301056 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40
+	Hs
		301043 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74
+	Hs
		72134 RNF37_HUMAN (1-541): 0: 1014: 100.00		B3KSH4_HUMAN (104-200): 1.63e-61: 187: 100.00