HitPredict

Interactor 1: MTCL2 (O94964)
Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]
Gene: MTCL2

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1661 Hs			1 245
+	Hs
		301277 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		301263 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		301266 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		301276 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		301282 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		301267 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		683848 MTCL1_HUMAN (1-1119): 7.77e-57: 220: 33.25		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		927055 NUMA1_HUMAN (2-1342): 1.76e-42: 173: 10.54		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		646898 NUMA1_HUMAN (2-1342): 1.76e-42: 173: 10.54		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		905298 MTCL1_HUMAN (1-1119): 7.77e-57: 220: 33.25		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982655 MTCL1_HUMAN (1-1119): 7.77e-57: 220: 33.25		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Mm
		926855 MYH9_MOUSE (758-1304): 6.72e-18: 92.8: 10.13		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		522602 MYH7_HUMAN (43-625): 2.06e-18: 94.7: 9.93		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		927643 MYH2_HUMAN (738-1385): 1.68e-18: 94.7: 8.01		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		724761 MYH9_HUMAN (724-1296): 2.97e-18: 93.9: 9.74		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		502907 MYH3_HUMAN (738-1385): 4.34e-16: 87: 8.17		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		522590 MYH7_HUMAN (43-625): 2.06e-18: 94.7: 9.93		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		647370 MYH2_HUMAN (738-1385): 1.68e-18: 94.7: 8.01		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		646681 MYH9_HUMAN (724-1296): 2.97e-18: 93.9: 9.74		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		725128 MYH10_HUMAN (858-1416): 2.04e-15: 84.7: 10.38		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59