HitPredict

Interactor 1: MTCL2 (O94964)
Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]
Gene: MTCL2

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005874 - microtubule GO:0030496 - midbody
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1661 Hs			1 669
+	Hs
		301339 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06
+	Hs
		301288 MTCL2_HUMAN (1-1661): 5.75e-170: 560: 100.00		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Mm
		1157654 MTCL3_MOUSE (5-747): 2.31e-91: 321: 37.55		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		1377831 MTCL1_HUMAN (1-1119): 7.77e-57: 220: 33.25		MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24
+	Hs
		846972 NUMA1_HUMAN (2-1342): 1.76e-42: 173: 10.54		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		148553 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		SMCA2_HUMAN (18-531): 1.58e-34: 143: 13.60
+	Hs
		148554 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		148830 NUMA1_HUMAN (2-1342): 1.76e-42: 173: 10.54		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		148801 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		149126 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		148466 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		MYH11_HUMAN (141-564): 3.93e-11: 68.9: 11.53
+	Hs
		148841 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		148126 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		148461 CTRO_HUMAN (184-1015): 5.73e-38: 158: 13.74		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Dm
		404213 MYSA_DROME (208-947): 4.55e-25: 116: 13.91		MYSA_DROME (329-654): 6.59e-14: 77.9: 14.65
+	Dm
		1303379 MYSN_DROME (75-729): 1.49e-19: 98.5: 11.82		MYSN_DROME (321-639): 1.56e-12: 73.5: 17.45
+	Hs
		528432 MYH8_HUMAN (738-1385): 2.91e-18: 93.9: 7.86		MYH13_HUMAN (161-669): 3.57e-13: 75.4: 11.94
+	Hs
		522657 MYH7_HUMAN (43-625): 2.06e-18: 94.7: 9.93		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		528435 MYH8_HUMAN (738-1385): 2.91e-18: 93.9: 7.86		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		522585 MYH7_HUMAN (43-625): 2.06e-18: 94.7: 9.93		MYH7_HUMAN (140-540): 9.01e-09: 61.2: 9.45