HitPredict

Interactor 1: UBP19 (O94966)
Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)
Gene: USP19

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

Property	Details
Experiments	28190767, 29576527, 33141564, 38803224, 35613680, 24356957
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1318 Hs			1 685
+	Hs
		475693 UBP4_HUMAN (487-1222): 5.62e-156: 496: 32.44		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476624 UBP15_HUMAN (485-1219): 1.01e-155: 496: 33.42		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475502 UBP11_HUMAN (459-1228): 1.44e-151: 484: 30.84		UBC_HUMAN (1-685): 0: 846: 100.00
+	Mm
		476793 UBP19_MOUSE (1-1318): 0: 1156: 81.03		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		271022 UBP2_HUMAN (796-1219): 6.05e-73: 257: 20.54		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475440 UBP8_HUMAN (781-1222): 3.94e-67: 250: 19.39		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476579 UBP22_HUMAN (458-838): 9.18e-65: 231: 19.02		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475954 UBP31_HUMAN (1019-1216): 1.82e-57: 220: 35.46		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		64200 UBP27_HUMAN (493-677): 1.53e-59: 213: 29.73		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sc
		477284 UBP12_YEAST (454-1251): 7.03e-128: 427: 26.01		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		1210479 UBP15_ARATH (296-972): 8.77e-60: 225: 11.03		UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80
+	Rn
		70290 UBP4_RAT (342-1250): 1.13e-160: 508: 29.27		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476695 UBP4_MOUSE (342-1244): 1.96e-157: 500: 28.15		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476926 UBP15_MOUSE (485-1219): 1.25e-154: 493: 33.42		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476963 UBP11_MOUSE (431-1248): 8.78e-148: 473: 29.78		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	At
		1092065 UBP15_ARATH (296-972): 8.77e-60: 225: 11.03		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Rn
		1137288 UBP2_RAT (770-1219): 5.39e-71: 252: 19.62		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476865 UBP8_MOUSE (684-1222): 4.39e-67: 249: 15.95		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		271114 UBP2_HUMAN (796-1219): 6.05e-73: 257: 20.54		Q5U5U6_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		477008 UBP12_MOUSE (478-784): 3.13e-61: 216: 16.56		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74