HitPredict

Interactor 1: TRI37 (O94972)
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Gene: TRIM37

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33194618, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0042803 - protein homodimerization activity GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 964 Hs			1 724
+	Hs
		301553 TRI37_HUMAN (1-964): 0: 1280: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		301590 TRI37_HUMAN (1-964): 0: 1280: 100.00		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		437880 RO52_HUMAN (1-393): 1.7e-71: 246: 16.54		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438502 TRIM6_HUMAN (1-360): 9.92e-70: 242: 17.10		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438503 TRIM2_HUMAN (7-254): 6.61e-66: 238: 22.79		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432239 TRIM2_HUMAN (7-254): 6.61e-66: 238: 22.79		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437829 TRI49_HUMAN (1-377): 5.61e-63: 222: 14.07		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438587 TRI10_HUMAN (1-408): 1.28e-60: 216: 16.04		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438501 TRIM7_HUMAN (10-361): 1.45e-58: 211: 15.83		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438500 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431456 TRI49_HUMAN (1-377): 5.61e-63: 222: 14.07		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438654 TRI17_HUMAN (1-343): 4.52e-57: 206: 18.21		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432329 TRI10_HUMAN (1-408): 1.28e-60: 216: 16.04		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432238 TRIM7_HUMAN (10-361): 1.45e-58: 211: 15.83		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432399 TRI17_HUMAN (1-343): 4.52e-57: 206: 18.21		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431986 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538271 TRI68_HUMAN (1-372): 6.51e-66: 231: 16.00		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		62676 TRI64_HUMAN (1-372): 4.32e-62: 219: 14.51		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		584990 RO52_HUMAN (1-393): 1.7e-71: 246: 16.54		Q6PK50_HUMAN (1-350): 0: 618: 99.71
+	Hs
		1162539 TRI17_HUMAN (1-343): 4.52e-57: 206: 18.21		Q6PK50_HUMAN (1-350): 0: 618: 99.71