HitPredict

Interactor 1: TRI37 (O94972)
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Gene: TRIM37

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33194618, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 964 Hs			1 639
+	Hs
		301540 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		301560 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62
+	Hs
		301526 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		301586 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		301525 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		301515 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		301896 TRI37_HUMAN (1-964): 0: 1280: 100.00		K2C74_HUMAN (1-563): 1.33e-76: 255: 51.69
+	Hs
		380552 TRI27_HUMAN (1-373): 2.44e-71: 247: 16.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		380683 TRIM7_HUMAN (10-361): 1.45e-58: 211: 15.83		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		380682 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		318774 TRI27_HUMAN (1-373): 2.44e-71: 247: 16.00		K2C75_HUMAN (1-582): 6e-90: 291: 53.58
+	Hs
		531606 TRI58_HUMAN (1-372): 1.91e-67: 235: 16.15		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		536787 TRI27_HUMAN (1-373): 2.44e-71: 247: 16.00		K22O_HUMAN (1-506): 1.14e-73: 250: 63.95
+	Hs
		380469 TRI26_HUMAN (1-299): 2e-58: 211: 18.10		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		531626 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		821686 TRIM7_HUMAN (10-361): 1.45e-58: 211: 15.83		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		517736 TRI27_HUMAN (1-373): 2.44e-71: 247: 16.00		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32
+	Hs
		1062065 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		K2C72_HUMAN (87-494): 7.09e-77: 255: 61.28
+	Hs
		729168 TRIM7_HUMAN (10-361): 1.45e-58: 211: 15.83		K22E_HUMAN (1-517): 4.22e-68: 235: 100.00
+	Hs
		729167 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		K22E_HUMAN (1-517): 4.22e-68: 235: 100.00