HitPredict

Interactor 1: TRI37 (O94972)
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Gene: TRIM37

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32908313
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003713 - transcription coactivator activity GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 964 Hs			1 2555
+	Hs
		804274 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		262156 TRIM3_HUMAN (13-254): 2.26e-50: 192: 21.76		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		301918 TRI37_HUMAN (1-964): 0: 1280: 100.00		ANKH1_HUMAN (1617-2544): 8.61e-80: 297: 12.51
+	Hs
		301649 TRI37_HUMAN (1-964): 0: 1280: 100.00		FBN2_HUMAN (573-1697): 5.09e-30: 133: 15.09
+	Hs
		301648 TRI37_HUMAN (1-964): 0: 1280: 100.00		FBN1_HUMAN (963-1746): 1.33e-14: 82.7: 14.70
+	Hs
		301776 TRI37_HUMAN (1-964): 0: 1280: 100.00		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		965126 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67
+	Hs
		1021420 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60
+	Hs
		1172237 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANR50_HUMAN (1862-2553): 1.06e-91: 332: 15.85
+	Hs
		556708 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANK1_HUMAN (1963-2550): 1.92e-90: 331: 12.75
+	Hs
		1170718 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANKH1_HUMAN (1617-2544): 8.61e-80: 297: 12.51
+	Hs
		257636 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANR17_HUMAN (1919-2553): 8.85e-80: 297: 13.87
+	Hs
		1170824 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72
+	Hs
		1170834 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		ANR52_HUMAN (1998-2492): 2.36e-64: 242: 13.80
+	Hs
		944121 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		JAG1_HUMAN (8-429): 2.99e-40: 166: 25.26
+	Hs
		724374 TRI68_HUMAN (1-372): 6.51e-66: 231: 16.00		FBN2_HUMAN (573-1697): 5.09e-30: 133: 15.09
+	Hs
		1059068 TRI68_HUMAN (1-372): 6.51e-66: 231: 16.00		LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27
+	Hs
		724379 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		FBN2_HUMAN (573-1697): 5.09e-30: 133: 15.09
+	Hs
		624333 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		TENA_HUMAN (1356-1565): 3.2e-18: 94.5: 20.94
+	Hs
		1126605 TRI67_HUMAN (2-368): 1.83e-54: 205: 15.93		CRUM2_HUMAN (12-142): 2.04e-11: 72.2: 32.61