HitPredict

Interactor 1: TRI37 (O94972)
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Gene: TRIM37

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30254148, 32572790
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0042803 - protein homodimerization activity GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 964 Hs			1 419
+	Hs
		302063 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		301596 TRI37_HUMAN (1-964): 0: 1280: 100.00		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		301650 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		301651 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		301580 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		301948 TRI37_HUMAN (1-964): 0: 1280: 100.00		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		302035 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYH2_HUMAN (1-396): 8.43e-09: 60: 9.77
+	Hs
		302067 TRI37_HUMAN (1-964): 0: 1280: 100.00		MYH4_HUMAN (21-393): 8.88e-09: 60: 13.44
+	Hs
		1223395 TRI22_HUMAN (1-389): 1.09e-67: 237: 17.00		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1318722 TRIM5_HUMAN (1-389): 6.39e-67: 234: 18.03		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1019390 TRI26_HUMAN (1-299): 2e-58: 211: 18.10		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		585030 RO52_HUMAN (1-393): 1.7e-71: 246: 16.54		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1318539 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1078906 TRIM5_HUMAN (1-389): 6.39e-67: 234: 18.03		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		522639 TRIM6_HUMAN (1-360): 9.92e-70: 242: 17.10		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528393 TRIM6_HUMAN (1-360): 9.92e-70: 242: 17.10		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		1357714 TRI35_HUMAN (5-371): 7.76e-65: 228: 16.71		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Hs
		725005 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725238 TRI31_HUMAN (1-287): 1.23e-58: 209: 17.11		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Mm
		1093546 TRI72_MOUSE (3-319): 6.9e-58: 208: 15.98		MYH9_MOUSE (18-363): 2.99e-10: 64.6: 13.75