HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.736

The method score is based on:

Property Details
Experiments 24189400, 8548289, 31959764, 35384245, 23956138, 24797263
Identification Methods affinity chromatography technology, pull down, proximity labelling technology, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
GO:0030669 - clathrin-coated endocytic vesicle membrane
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 939
Hs

1 1210
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Last updated: 15 Jul 2024