HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 939 Hs			1 864
+	Hs
		321661 AP2A1_HUMAN (1-939): 0: 832: 78.47		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		302112 AP2A2_HUMAN (1-939): 0: 884: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		567515 AP2A2_MOUSE (1-939): 0: 891: 96.70		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		321504 AP2A1_HUMAN (1-939): 0: 832: 78.47		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Rn
		1126749 Q66HM2_RAT (1-939): 0: 886: 96.28		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Rn
		88764 D3ZUY8_RAT (1-939): 0: 836: 81.17		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Hs
		302157 AP2A2_HUMAN (1-939): 0: 884: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		212604 AP1G1_HUMAN (1-811): 0: 616: 25.12		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		787890 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		321552 AP2A1_HUMAN (1-939): 0: 832: 78.47		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		88768 D3ZUY8_RAT (1-939): 0: 836: 81.17		ITSN1_RAT (16-526): 9.71e-29: 126: 12.87
+	Ce
		1094946 Q22601_CAEEL (1-939): 0: 794: 64.55		Q9U2T9_CAEEL (119-652): 4.86e-35: 146: 17.92
+	Mm
		788007 AP2B1_MOUSE (36-933): 0: 607: 16.51		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Rn
		923853 AP2B1_RAT (36-933): 0: 607: 16.62		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Hs
		321640 AP2A1_HUMAN (1-939): 0: 832: 78.47		EHD1_HUMAN (198-366): 4.94e-14: 77.8: 25.44
+	Hs
		321600 AP2A1_HUMAN (1-939): 0: 832: 78.47		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42
+	Dm
		91156 AP2A_DROME (3-939): 0: 819: 69.50		E3CTP7_DROME (504-831): 1.9e-12: 73.2: 8.54
+	Hs
		925876 AP2B1_HUMAN (36-933): 0: 607: 16.62		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		923861 AP2B1_RAT (36-933): 0: 607: 16.62		ITSN1_RAT (16-526): 9.71e-29: 126: 12.87
+	Hs
		926031 AP2B1_HUMAN (36-933): 0: 607: 16.62		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86