HitPredict

Interactor 1: DIRA1 (O95057)
GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1)
Gene: DIRAS1

Interactor 2: DIRA2 (Q96HU8)
GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2)
Gene: DIRAS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019003 - GDP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 198 Hs			1 199
+	Hs
		918874 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAB1A_HUMAN (2-197): 3.4e-82: 244: 29.70
+	Mm
		918986 RAB35_MOUSE (3-196): 3.21e-86: 254: 29.35		RAB1A_MOUSE (2-197): 3.4e-82: 244: 29.70
+	Mm
		1161510 RAB35_MOUSE (3-196): 3.21e-86: 254: 29.35		RAB13_MOUSE (4-198): 1.56e-81: 242: 30.15
+	Mm
		895595 RAB35_MOUSE (3-196): 3.21e-86: 254: 29.35		RAB8B_MOUSE (4-199): 1.58e-81: 242: 26.83
+	Mm
		1161509 RAB35_MOUSE (3-196): 3.21e-86: 254: 29.35		RAB1B_MOUSE (2-196): 5.7e-81: 241: 29.85
+	Hs
		845854 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAB13_HUMAN (4-198): 7.52e-81: 240: 28.00
+	Zm
		73944 B4FAE1_MAIZE (2-196): 6.37e-83: 245: 27.59		B4FAE1_MAIZE (2-197): 3.19e-83: 246: 29.21
+	Hs
		894715 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAB1A_HUMAN (2-197): 3.4e-82: 244: 29.70
+	Hs
		894787 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAB8B_HUMAN (4-199): 2.97e-81: 241: 26.83
+	Hs
		845844 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAB13_HUMAN (4-198): 7.52e-81: 240: 28.00
+	Hs
		845875 RAB13_HUMAN (4-197): 9.67e-80: 238: 29.00		RAB8B_HUMAN (4-199): 2.97e-81: 241: 26.83
+	Hs
		845881 RAB13_HUMAN (4-197): 9.67e-80: 238: 29.00		RAB1B_HUMAN (2-196): 2.25e-81: 241: 29.85
+	Mm
		919000 RAB1A_MOUSE (2-196): 7e-80: 238: 28.71		RAB1B_MOUSE (2-196): 5.7e-81: 241: 29.85
+	Hs
		845843 RAB13_HUMAN (4-197): 9.67e-80: 238: 29.00		RAB13_HUMAN (4-198): 7.52e-81: 240: 28.00
+	Hs
		894712 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RB11A_HUMAN (3-197): 7.48e-77: 231: 26.79
+	Hs
		845845 RAB13_HUMAN (4-197): 9.67e-80: 238: 29.00		RB11A_HUMAN (3-197): 7.48e-77: 231: 26.79
+	Hs
		896605 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RAB14_HUMAN (3-196): 9.54e-76: 228: 23.22
+	Hs
		919632 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAP1A_HUMAN (7-173): 2.58e-46: 152: 45.83