HitPredict

Interactor 1: CCNB2 (O95067)
G2/mitotic-specific cyclin-B2
Gene: CCNB2

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	15232106, 26186194, 28514442, 33961781, 23455922
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, protein array, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Hs			1 298
+	Hs
		538471 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		303821 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		538521 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		303843 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		625350 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Gg
		533892 CCNB2_CHICK (1-395): 4.38e-138: 401: 69.25		CDK1_CHICK (1-291): 1.09e-142: 405: 67.12
+	Hs
		414711 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		303844 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK17_HUMAN (1-296): 1.29e-122: 362: 52.53
+	Mm
		509465 CCNB1_MOUSE (1-395): 1e-130: 384: 44.39		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Xl
		526765 CCNB1_XENLA (1-395): 2.95e-129: 379: 47.37		CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12
+	Mm
		956329 CCNA1_MOUSE (16-388): 4.58e-114: 341: 30.85		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Hs
		538522 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		414855 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		538497 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	At
		621661 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62
+	At
		1103350 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB12_ARATH (1-291): 3.9e-133: 381: 56.31
+	At
		1106906 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB21_ARATH (1-294): 1.78e-131: 377: 54.13
+	At
		1106907 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB22_ARATH (1-294): 8.52e-131: 375: 55.45
+	At
		639373 CCB24_ARATH (19-387): 2.16e-111: 334: 30.65		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03
+	At
		639340 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03