HitPredict

Interactor 1: CCNB2 (O95067)
G2/mitotic-specific cyclin-B2
Gene: CCNB2

Interactor 2: PMYT1 (Q99640)
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)
Gene: PKMYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	26496610, 33961781, 35271311, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 398 Hs			1 499
+	Hs
		538598 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		PMYT1_HUMAN (1-499): 3.82e-135: 401: 100.00
+	Hs
		303829 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK2_HUMAN (107-360): 2.87e-100: 305: 27.43
+	Hs
		590218 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		PMYT1_HUMAN (1-499): 3.82e-135: 401: 100.00
+	Hs
		590134 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		AKT2_HUMAN (3-429): 1.86e-134: 399: 21.35
+	Hs
		590133 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		AKT1_HUMAN (3-428): 3.62e-133: 395: 20.59
+	Hs
		590239 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		AKT3_HUMAN (18-405): 2.16e-131: 391: 20.39
+	Hs
		590168 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		KPCT_HUMAN (59-424): 1.94e-127: 388: 19.42
+	Hs
		538471 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK2_HUMAN (107-360): 2.87e-100: 305: 27.43
+	Hs
		625350 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		CDK2_HUMAN (107-360): 2.87e-100: 305: 27.43
+	Hs
		590125 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		CDK2_HUMAN (107-360): 2.87e-100: 305: 27.43
+	Hs
		538479 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		WEE1_HUMAN (100-359): 5.49e-33: 134: 34.59
+	Xl
		526769 CCNB2_XENLA (1-394): 8.76e-132: 385: 59.65		WEE1B_XENLA (100-359): 5.06e-34: 137: 33.33
+	Hs
		538521 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK3_HUMAN (110-362): 3.53e-20: 92.8: 28.22
+	Hs
		673266 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		WEE1_HUMAN (100-359): 5.49e-33: 134: 34.59
+	Sc
		624678 CG22_YEAST (6-381): 2.1e-104: 318: 34.03		SWE1_YEAST (100-320): 1.08e-24: 110: 31.38
+	Hs
		590162 CCNA2_HUMAN (4-385): 1.85e-103: 314: 28.16		CDK3_HUMAN (110-362): 3.53e-20: 92.8: 28.22