HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	21118991, 36779422
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 420
+	Hs
		304074 UBR5_HUMAN (1-2799): 0: 3949: 100.00		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75
+	Hs
		304032 UBR5_HUMAN (1-2799): 0: 3949: 100.00		MK03_HUMAN (43-346): 2.41e-51: 178: 34.54
+	Dm
		576310 HYD_DROME (2133-2799): 0: 637: 49.63		SGG_DROME (1-393): 8.87e-144: 421: 77.16
+	Hs
		836051 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		836001 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		960116 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		CDK3_HUMAN (53-348): 5.47e-137: 396: 31.91
+	Hs
		165281 AREL1_HUMAN (2516-2798): 1.07e-22: 108: 29.05		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		835686 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Dm
		576520 SMUF1_DROME (2516-2792): 4.36e-20: 100: 27.34		SGG_DROME (1-393): 8.87e-144: 421: 77.16