HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005829 - cytosol GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 183
+	Hs
		304110 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		304101 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		304280 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00
+	Hs
		304298 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33
+	Hs
		304067 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2A_HUMAN (4-150): 8.87e-65: 197: 30.46
+	Hs
		304080 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		304114 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2B_HUMAN (4-149): 8e-64: 195: 30.67
+	Hs
		919762 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849351 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895825 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		919889 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		895935 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		919869 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849452 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895919 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		919867 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849451 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		849411 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895918 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		851871 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33