HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: RS27A (P62979)
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Gene: RPS27A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31365120
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	E3_UbLigase_EDD~ubiquitin, HECT~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 156
+	Mm
		476862 UBR5_MOUSE (1-2799): 0: 3938: 97.89		UBC_MOUSE (1-119): 1.07e-36: 135: 67.48
+	Hs
		125347 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		924156 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Sc
		408371 RSP5_YEAST (2187-2797): 2.89e-122: 409: 16.98		RS31_YEAST (1-151): 4.55e-61: 187: 82.78
+	Mm
		924239 HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27		RS27A_MOUSE (1-156): 8.08e-76: 224: 99.36
+	Sp
		145416 PUB3_SCHPO (2427-2797): 1.57e-121: 407: 23.56		RS27A_SCHPO (1-151): 1.04e-57: 178: 81.46
+	Sp
		145417 PUB3_SCHPO (2427-2797): 1.57e-121: 407: 23.56		RS27B_SCHPO (1-151): 8.29e-58: 178: 81.46
+	Hs
		924414 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Rn
		1140970 Q5YB86_RAT (2187-2797): 2.68e-133: 443: 18.24		UBC_RAT (1-119): 1.57e-36: 134: 68.29
+	Mm
		476866 UBE3C_MOUSE (2301-2796): 1.1e-128: 437: 20.33		UBC_MOUSE (1-119): 1.07e-36: 135: 67.48
+	Dm
		89880 D5SHR3_DROME (2366-2797): 2.99e-133: 427: 20.81		RL40_DROME (1-125): 1.01e-43: 142: 64.80
+	Hs
		475196 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Hs
		475140 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	At
		1091758 UPL1_ARATH (2398-2798): 1.97e-122: 438: 22.30		UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81
+	At
		1091762 UPL2_ARATH (2398-2798): 1.26e-121: 435: 22.54		UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81
+	Hs
		125112 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Dm
		1376481 Q9W325_DROME (2355-2797): 3.11e-133: 427: 20.52		Q9W418_DROME (1-77): 1.7e-34: 127: 100.00
+	Sp
		145418 PUB3_SCHPO (2427-2797): 1.57e-121: 407: 23.56		RL402_SCHPO (1-125): 7.03e-41: 135: 63.20
+	Hs
		474953 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Mm
		476858 HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27		UBC_MOUSE (1-119): 1.07e-36: 135: 67.48