HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: NBEL2 (Q6ZNJ1)
Neurobeachin-like protein 2
Gene: NBEAL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	29187380
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 2754
+	Hs
		304102 UBR5_HUMAN (1-2799): 0: 3949: 100.00		WDR5_HUMAN (2586-2753): 1.82e-40: 156: 8.72
+	Hs
		1169405 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		NBEL2_HUMAN (1-2754): 0: 2873: 100.00
+	Hs
		125310 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		WDR5_HUMAN (2586-2753): 1.82e-40: 156: 8.72
+	Hs
		929669 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		RACK1_HUMAN (2590-2751): 4.46e-20: 95.7: 14.02
+	Hs
		125355 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		RACK1_HUMAN (2590-2751): 4.46e-20: 95.7: 14.02
+	Mm
		1129463 HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27		WDR81_MOUSE (2494-2725): 1.16e-24: 116: 19.33
+	Hs
		1192155 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		FBXW7_HUMAN (2358-2525): 6.44e-20: 99.6: 13.64
+	Hs
		929534 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		RACK1_HUMAN (2590-2751): 4.46e-20: 95.7: 14.02
+	Hs
		903156 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		WDR5_HUMAN (2586-2753): 1.82e-40: 156: 8.72