HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: WDR48 (Q8TAF3)
WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)
Gene: WDR48

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	28689657, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response and 1 others more... GO:0043130 - ubiquitin binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 677
+	Hs
		304289 UBR5_HUMAN (1-2799): 0: 3949: 100.00		SNR40_HUMAN (202-466): 3.02e-53: 188: 15.13
+	Hs
		304102 UBR5_HUMAN (1-2799): 0: 3949: 100.00		WDR5_HUMAN (244-509): 1.61e-43: 161: 13.70
+	Hs
		304390 UBR5_HUMAN (1-2799): 0: 3949: 100.00		FBW1B_HUMAN (11-282): 1.55e-18: 91.3: 28.68
+	Hs
		1251227 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		WDR48_HUMAN (1-677): 0: 537: 100.00
+	Hs
		125310 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		WDR5_HUMAN (244-509): 1.61e-43: 161: 13.70
+	Hs
		125414 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		TBL3_HUMAN (74-293): 3.32e-09: 62.4: 24.14
+	Hs
		1192257 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		FBW1B_HUMAN (11-282): 1.55e-18: 91.3: 28.68
+	Hs
		1192155 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		FBXW7_HUMAN (330-498): 9.76e-09: 60.4: 10.06
+	Hs
		903156 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		WDR5_HUMAN (244-509): 1.61e-43: 161: 13.70