HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: RCOR1 (Q9UKL0)
REST corepressor 1 (Protein CoREST)
Gene: RCOR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 34709266
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 485
+	Hs
		1192258 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		RCOR1_HUMAN (1-485): 5.94e-148: 433: 100.00
+	Hs
		1031865 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		MTA1_HUMAN (81-410): 5.09e-71: 241: 16.03
+	Hs
		1294838 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		TREF1_HUMAN (47-410): 7.44e-63: 223: 17.28
+	Hs
		296032 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		MTA2_HUMAN (85-446): 1.69e-64: 222: 16.67
+	Hs
		808234 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		TREF1_HUMAN (47-410): 7.44e-63: 223: 17.28
+	Hs
		125526 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		MDEAS_HUMAN (105-381): 6.79e-46: 173: 16.67
+	Ce
		998288 Q9GUP2_CAEEL (2526-2798): 1.6e-17: 92.8: 26.86		EGL27_CAEEL (90-396): 1.63e-51: 190: 15.59