HitPredict - High confidence protein-protein interactions

Interactor 1: MFN2 (O95140)
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)
Gene: MFN2

Interactor 2: MFN2 (O95140)
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)
Gene: MFN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	31416892, 23727017, 19052620
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Dynamin_N~Dynamin_N, Dynamin_N~Fzo_mitofusin, Fzo_mitofusin~Fzo_mitofusin
Common GO terms	GO:0001825 - blastocyst formation GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane and 18 others more... GO:0005829 - cytosol GO:0006626 - protein targeting to mitochondrion GO:0006915 - apoptotic process GO:0006986 - response to unfolded protein GO:0007006 - mitochondrial membrane organization GO:0008053 - mitochondrial fusion GO:0009060 - aerobic respiration GO:0015630 - microtubule cytoskeleton GO:0031625 - ubiquitin protein ligase binding GO:0034497 - protein localization to phagophore assembly site GO:0046580 - negative regulation of Ras protein signal transduction GO:0048593 - camera-type eye morphogenesis GO:0048662 - negative regulation of smooth muscle cell proliferation GO:0051646 - mitochondrion localization GO:0061734 - parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization GO:0120162 - positive regulation of cold-induced thermogenesis GO:1904707 - positive regulation of vascular associated smooth muscle cell proliferation GO:1905461 - positive regulation of vascular associated smooth muscle cell apoptotic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	757
Hs

1	757

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Last updated: 15 Jul 2024