HitPredict

Interactor 1: MFN2 (O95140)
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)
Gene: MFN2

Interactor 2: MFN1 (Q8IWA4)
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Gene: MFN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	28514442, 33961781, 35271311, 27713096, 19052620
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Dynamin_N~Dynamin_N, Dynamin_N~Fzo_mitofusin, Fzo_mitofusin~Fzo_mitofusin
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0008053 - mitochondrial fusion and 1 others more... GO:0051646 - mitochondrion localization
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 757 Hs			1 741
+	Mm
		1193516 MFN2_MOUSE (1-757): 0: 1228: 94.98		MFN1_MOUSE (1-741): 0: 1198: 90.55
+	Hs
		304772 MFN2_HUMAN (1-757): 0: 1231: 100.00		MFN2_HUMAN (1-737): 0: 1096: 63.46
+	Hs
		1218390 MFN1_HUMAN (21-756): 0: 1115: 63.14		MFN1_HUMAN (1-741): 0: 1182: 100.00