HitPredict

Interactor 1: TNF15 (O95150)
Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]
Gene: TNFSF15

Interactor 2: TNF6B (O95407)
Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68)
Gene: TNFRSF6B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	11911831, 21300286
Identification Methods	affinity chromatography technology, x-ray crystallography, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	TNF~TNFR_c6
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 251 Hs			1 300
+	Hs
		313618 TNFL6_HUMAN (29-251): 7.31e-63: 200: 23.89		TNF6B_HUMAN (1-300): 1.31e-92: 278: 100.00
+	Hs
		305095 TNF15_HUMAN (1-251): 5.36e-117: 336: 100.00		TNR25_HUMAN (31-159): 6.1e-20: 91: 18.31
+	Hs
		352486 TNFA_HUMAN (29-251): 9.48e-70: 215: 26.41		TNR1B_HUMAN (3-245): 5.33e-59: 196: 28.51
+	Hs
		124653 TNF11_HUMAN (62-251): 5.36e-58: 188: 24.00		TR11B_HUMAN (11-236): 4.03e-69: 221: 36.40
+	Mm
		139718 TNF11_MOUSE (62-251): 3.73e-58: 188: 25.13		TR11B_MOUSE (10-236): 2.8e-66: 214: 36.68
+	Hs
		352517 TNFA_HUMAN (29-251): 9.48e-70: 215: 26.41		TNR3_HUMAN (3-249): 1.17e-54: 185: 28.41
+	Mm
		420391 TNFA_MOUSE (47-251): 1.67e-66: 207: 24.77		TNR1B_MOUSE (9-236): 2.31e-55: 187: 27.12
+	Rn
		561443 TNFA_RAT (47-251): 2.47e-65: 204: 25.23		TNR1B_RAT (9-236): 3.34e-50: 174: 25.85
+	Mm
		192442 TNF11_MOUSE (62-251): 3.73e-58: 188: 25.13		TNR11_MOUSE (2-208): 2.75e-50: 177: 29.05
+	Hs
		155704 TNF11_HUMAN (62-251): 5.36e-58: 188: 24.00		TNR11_HUMAN (33-206): 2.82e-43: 158: 29.38
+	Mm
		838554 TNF14_MOUSE (76-251): 9.48e-54: 175: 26.26		TNR3_MOUSE (2-246): 3.5e-45: 159: 26.04
+	Hs
		352484 TNFA_HUMAN (29-251): 9.48e-70: 215: 26.41		TNR1A_HUMAN (36-191): 1.76e-29: 118: 23.35
+	Rn
		561403 TNFA_RAT (47-251): 2.47e-65: 204: 25.23		TNR1A_RAT (36-191): 3.7e-32: 125: 21.69
+	Mm
		420390 TNFA_MOUSE (47-251): 1.67e-66: 207: 24.77		TNR1A_MOUSE (36-246): 2.18e-30: 120: 18.86
+	Hs
		352497 TNFA_HUMAN (29-251): 9.48e-70: 215: 26.41		TNR6_HUMAN (43-152): 2.73e-26: 107: 27.59
+	Hs
		584344 TNFL6_HUMAN (29-251): 7.31e-63: 200: 23.89		TNR1A_HUMAN (36-191): 1.76e-29: 118: 23.35
+	Mm
		1174754 TNF14_MOUSE (76-251): 9.48e-54: 175: 26.26		Q71F55_MOUSE (18-196): 1.18e-39: 141: 31.72
+	Hs
		632214 TNFL6_HUMAN (29-251): 7.31e-63: 200: 23.89		TNR6_HUMAN (43-152): 2.73e-26: 107: 27.59
+	Mm
		632460 TNFL6_MOUSE (25-251): 1.62e-65: 206: 26.96		TNR6_MOUSE (13-155): 3.21e-24: 101: 24.53
+	Hs
		154325 TNFL6_HUMAN (29-251): 7.31e-63: 200: 23.89		TR10B_HUMAN (25-157): 4.23e-22: 97.2: 22.46