HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: WDFY3 (Q8IZQ1)
WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
Gene: WDFY3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	24668264, 20562859
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000421 - autophagosome membrane GO:0005776 - autophagosome GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 3526
+	Hs
		891218 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Hs
		1152287 Q6IAW1_HUMAN (1-117): 8.06e-57: 173: 100.00		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Hs
		1224700 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Hs
		1224703 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Hs
		1224697 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Mm
		1167198 MLP3A_MOUSE (5-117): 2.29e-45: 144: 30.44		WDFY3_MOUSE (1-3526): 0: 4181: 95.97
+	Dm
		1370863 Q9W2S2_DROME (1-117): 5.29e-58: 176: 91.45		Q9VML2_DROME (9-3517): 0: 3285: 46.36
+	Hs
		891255 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		FAN_HUMAN (2475-3286): 1.81e-176: 571: 25.26
+	Hs
		306258 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		FAN_HUMAN (2475-3286): 1.81e-176: 571: 25.26
+	Hs
		1268699 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		FAN_HUMAN (2475-3286): 1.81e-176: 571: 25.26
+	Hs
		1268700 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		FAN_HUMAN (2475-3286): 1.81e-176: 571: 25.26
+	Hs
		1268697 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		FAN_HUMAN (2475-3286): 1.81e-176: 571: 25.26
+	Hs
		891030 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		1122381 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		WDR81_HUMAN (2651-2991): 4.05e-71: 269: 27.73
+	Hs
		209414 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		PLRG1_HUMAN (2934-3299): 1.42e-38: 155: 13.66
+	Hs
		209368 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		PLRG1_HUMAN (2934-3299): 1.42e-38: 155: 13.66
+	At
		1248230 ATG8E_ARATH (2-116): 3.76e-59: 179: 57.39		FREE1_ARATH (3421-3525): 2.23e-31: 135: 30.56
+	Hs
		891348 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		ANFY1_HUMAN (3457-3510): 6e-10: 67.8: 46.30
+	Hs
		306344 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		ANFY1_HUMAN (3457-3510): 6e-10: 67.8: 46.30
+	Hs
		1328056 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		ANFY1_HUMAN (3457-3510): 6e-10: 67.8: 46.30