HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: ATG4C (Q96DT6)
Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C)
Gene: ATG4C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28287329
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0015031 - protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 458
+	Hs
		1288559 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		ATG4C_HUMAN (1-458): 0: 653: 100.00
+	Hs
		891203 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		ATG4D_HUMAN (7-458): 0: 557: 45.51
+	Hs
		306219 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		ATG4D_HUMAN (7-458): 0: 557: 45.51
+	Hs
		1198603 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		ATG4D_HUMAN (7-458): 0: 557: 45.51
+	Ce
		999365 LGG1_CAEEL (1-116): 2.47e-55: 170: 83.62		ATG42_CAEEL (11-424): 2.06e-132: 393: 26.08
+	Hs
		891370 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		ATG4B_HUMAN (39-420): 1.07e-128: 380: 26.65
+	Hs
		306368 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		ATG4B_HUMAN (39-420): 1.07e-128: 380: 26.65
+	Hs
		1328075 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		ATG4B_HUMAN (39-420): 1.07e-128: 380: 26.65
+	Hs
		891248 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		ATG4A_HUMAN (68-422): 3.87e-118: 353: 27.11
+	Hs
		306253 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		ATG4A_HUMAN (68-422): 3.87e-118: 353: 27.11
+	Mm
		1206409 MLP3A_MOUSE (5-117): 2.29e-45: 144: 30.44		ATG4B_MOUSE (39-454): 7.24e-129: 380: 25.28
+	Hs
		1330686 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		ATG4B_HUMAN (39-420): 1.07e-128: 380: 26.65
+	Hs
		1264549 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		ATG4A_HUMAN (68-422): 3.87e-118: 353: 27.11
+	Ce
		111920 LGG1_CAEEL (1-116): 2.47e-55: 170: 83.62		ATG41_CAEEL (75-422): 9.68e-108: 329: 23.21
+	Hs
		1264550 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		ATG4A_HUMAN (68-422): 3.87e-118: 353: 27.11
+	Dm
		1372164 Q9W2S2_DROME (1-117): 5.29e-58: 176: 91.45		Q9VPW2_DROME (37-429): 2.82e-104: 317: 28.89
+	Dm
		1179054 Q7K1J3_DROME (1-116): 4.56e-54: 167: 77.59		Q9VPW2_DROME (37-429): 2.82e-104: 317: 28.89
+	Dm
		114224 Q9VEG5_DROME (1-116): 5.35e-54: 166: 77.59		M9PBM3_DROME (37-429): 2.62e-104: 317: 28.89
+	Dm
		1364631 Q9VEG5_DROME (1-116): 5.35e-54: 166: 77.59		Q9VPW2_DROME (37-429): 2.82e-104: 317: 28.89
+	Sc
		746022 ATG8_YEAST (1-116): 9.18e-59: 178: 55.17		ATG4_YEAST (72-447): 1.38e-82: 264: 24.27