HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: VTI1A (Q96AJ9)
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)
Gene: VTI1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0005794 - Golgi apparatus GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 217
+	Hs
		261703 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00
+	At
		221565 VA711_ARATH (4-95): 5.3e-28: 103: 22.58		VTI11_ARATH (1-216): 4.44e-60: 189: 32.13
+	Hs
		1284295 VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03		VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00
+	Hs
		151537 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09
+	Hs
		263321 SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65		VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00
+	Hs
		1079397 VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03		VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00
+	Rn
		1144366 VAMP1_RAT (2-78): 9.26e-27: 97.3: 37.66		VTI1A_RAT (1-217): 2.13e-60: 190: 93.30
+	Dm
		1178140 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53
+	Dm
		1178131 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		GOSR2_DROME (5-212): 3.58e-50: 164: 18.14
+	Hs
		306885 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Mm
		291513 VAMP7_MOUSE (4-94): 1.74e-25: 96.9: 31.87		VTI1B_MOUSE (2-217): 4.1e-54: 174: 29.02
+	Dm
		577264 SYB_DROME (2-88): 9.74e-30: 105: 39.08		Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53
+	Dm
		577252 SYB_DROME (2-88): 9.74e-30: 105: 39.08		GOSR2_DROME (5-212): 3.58e-50: 164: 18.14
+	Rn
		192340 SC22B_RAT (2-86): 2.38e-23: 91.1: 17.65		GOSR2_RAT (5-212): 1.25e-55: 177: 15.49
+	Hs
		151535 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09
+	Hs
		151536 SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65		GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09
+	Hs
		850604 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Hs
		261737 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Hs
		1313462 VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Hs
		263387 SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80