HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~Synaptobrevin
Common GO terms	GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 100
+	Dm
		577225 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Hs
		306775 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		306798 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		850543 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		850567 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		620270 VAMP1_HUMAN (2-78): 6.73e-26: 95: 36.36		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1079421 VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		926210 VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		620263 VAMP1_HUMAN (2-78): 6.73e-26: 95: 36.36		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		926250 VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Rn
		926352 VAMP2_RAT (2-75): 2.33e-25: 93.8: 39.19		VAMP2_RAT (6-82): 2.47e-23: 88: 35.07
+	Hs
		1079323 VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		87581 VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03		C9JXZ5_HUMAN (27-100): 3.6e-20: 78.5: 100.00