HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	30833792, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005770 - late endosome GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 236
+	Hs
		235133 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Hs
		212700 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		235129 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Dm
		1178135 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		850607 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Rn
		1144363 VAMP1_RAT (2-78): 9.26e-27: 97.3: 37.66		STX6_RAT (3-222): 3.2e-46: 155: 17.65
+	Hs
		261740 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Dm
		577257 SYB_DROME (2-88): 9.74e-30: 105: 39.08		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	At
		1351793 VA721_ARATH (5-92): 9.82e-32: 113: 26.14		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	At
		812701 VA722_ARATH (5-92): 1.2e-30: 110: 25.00		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		212772 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		212689 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		306744 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169343 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Hs
		320281 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		261624 VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Dm
		577224 SYB_DROME (2-88): 9.74e-30: 105: 39.08		Q7JRF1_DROME (3-138): 1.1e-20: 90.3: 14.29
+	Hs
		169416 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1178137 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Dm
		577258 SYB_DROME (2-88): 9.74e-30: 105: 39.08		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00