HitPredict

Interactor 1: RTN3 (O95197)
Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)
Gene: RTN3

Interactor 2: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	33961781, 37931956, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1032 Hs			1 1104
+	Hs
		1311413 RTN4_HUMAN (64-1030): 9.26e-60: 225: 21.16		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		258966 RTN2_HUMAN (620-1024): 7.71e-50: 187: 22.49		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		1087788 RTN1_HUMAN (271-1028): 2.29e-45: 178: 22.73		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		48212 RTN3_HUMAN (1-1032): 0: 645: 100.00		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	At
		1341032 RTNLH_ARATH (790-1030): 8.2e-66: 224: 18.73		MCTP8_ARATH (802-1101): 2.61e-22: 105: 16.25
+	Hs
		48526 RTN4_HUMAN (64-1030): 9.26e-60: 225: 21.16		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48199 RTN2_HUMAN (620-1024): 7.71e-50: 187: 22.49		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32