HitPredict

Interactor 1: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Interactor 2: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.948

The method score is based on:

Property Details
Experiments 30190310, 32296183, 28514442, 33961781, 15383316, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~BTB, BTB~BTB, Kelch_1~Kelch_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:1990756 - ubiquitin-like ligase-substrate adaptor activity
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 593
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024