HitPredict

Interactor 1: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Interactor 2: WNK4 (Q96J92)
Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)
Gene: WNK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	23838290, 24641320
Identification Methods	affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 1243
+	Hs
		1294943 KLHL3_HUMAN (12-593): 0: 546: 77.66		WNK4_HUMAN (1-1243): 0: 695: 100.00
+	Hs
		682058 KLHL3_HUMAN (12-593): 0: 546: 77.66		AKT1_HUMAN (107-493): 8.76e-129: 405: 19.44
+	Hs
		307234 KLHL2_HUMAN (1-593): 0: 574: 100.00		WNK2_HUMAN (542-1102): 1.04e-36: 153: 22.65
+	Hs
		307211 KLHL2_HUMAN (1-593): 0: 574: 100.00		WNK3_HUMAN (567-1243): 1.13e-29: 130: 15.05
+	Hs
		1355222 KLHL3_HUMAN (12-593): 0: 546: 77.66		WNK2_HUMAN (542-1102): 1.04e-36: 153: 22.65
+	Hs
		307216 KLHL2_HUMAN (1-593): 0: 574: 100.00		WNK1_HUMAN (530-1064): 1.33e-27: 124: 21.27
+	Hs
		1317206 KLHL3_HUMAN (12-593): 0: 546: 77.66		WNK3_HUMAN (567-1243): 1.13e-29: 130: 15.05
+	Hs
		1330745 KLHL3_HUMAN (12-593): 0: 546: 77.66		WNK1_HUMAN (530-1064): 1.33e-27: 124: 21.27