HitPredict

Interactor 1: RCBT2 (O95199)
RCC1 and BTB domain-containing protein 2 (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor) (Regulator of chromosome condensation and BTB domain-containing protein 2)
Gene: RCBTB2

Interactor 2: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.612

Property	Details
Experiments	28514442, 33961781, 19256485
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 207
+	Hs
		849333 HERC3_HUMAN (2-334): 7.76e-94: 310: 24.72		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		1282362 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Hs
		1297377 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2E2_HUMAN (1-207): 5.59e-89: 261: 85.02
+	Hs
		919733 HERC1_HUMAN (2-222): 1.54e-58: 213: 26.96		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		895797 HERC1_HUMAN (2-222): 1.54e-58: 213: 26.96		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		919895 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		849478 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895943 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		851904 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Hs
		1242535 RCBT1_HUMAN (1-183): 1.26e-44: 167: 24.23		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Mm
		854554 RCBT1_MOUSE (1-183): 9.24e-45: 167: 24.74		UB2E3_MOUSE (1-207): 5.71e-90: 264: 100.00
+	Hs
		829082 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UBE2A_HUMAN (59-204): 1.17e-69: 210: 35.62
+	Hs
		896561 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Hs
		927786 HERC5_HUMAN (2-220): 5.92e-56: 204: 22.59		UBE2B_HUMAN (59-204): 8.05e-69: 209: 36.30
+	Hs
		1125824 HERC4_HUMAN (227-412): 1.79e-23: 107: 22.87		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Hs
		919741 HERC4_HUMAN (227-412): 1.79e-23: 107: 22.87		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		319786 HERC2_HUMAN (2-60): 5.66e-11: 67.8: 5.97		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		319766 HERC2_HUMAN (2-60): 5.66e-11: 67.8: 5.97		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		319780 HERC2_HUMAN (2-60): 5.66e-11: 67.8: 5.97		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		319781 HERC2_HUMAN (2-60): 5.66e-11: 67.8: 5.97		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27