HitPredict

Interactor 1: EPN2 (O95208)
Epsin-2 (EPS-15-interacting protein 2)
Gene: EPN2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	32296183, 28190767, 31699778, 38803224, 19285159, unassigned1304
Identification Methods	two hybrid, pull down, protein array, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 641 Hs			1 685
+	Hs
		476358 EPN3_HUMAN (1-636): 9.66e-68: 234: 32.04		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476657 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477525 Q7KU90_DROME (1-640): 8.53e-66: 232: 28.42		UBIQP_DROME (1-610): 0: 752: 99.84
+	Hs
		475943 OTOG_HUMAN (216-641): 4.64e-30: 129: 13.53		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sc
		477505 ENT1_YEAST (3-432): 4.62e-73: 244: 22.87		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Sc
		477449 ENT2_YEAST (3-234): 9.18e-60: 212: 32.76		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		307522 EPN2_HUMAN (1-641): 7.59e-111: 348: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Dm
		1182371 Q7KU90_DROME (1-640): 8.53e-66: 232: 28.42		R9PY16_DROME (457-685): 5.07e-80: 258: 90.39
+	Hs
		111209 I6L9I8_HUMAN (1-339): 1.48e-107: 329: 45.13		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	At
		1091714 EPN2_ARATH (2-641): 1.33e-53: 199: 21.00		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		476910 EPN2_MOUSE (1-641): 4.73e-102: 324: 70.36		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		397968 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		924159 EPN3_HUMAN (1-636): 9.66e-68: 234: 32.04		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		924231 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		291394 EPN1_RAT (1-570): 1.18e-64: 224: 39.17		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	At
		1092229 SC24C_ARATH (172-588): 3.24e-12: 72: 11.06		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		475183 EPN3_HUMAN (1-636): 9.66e-68: 234: 32.04		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		476869 EPN1_MOUSE (1-570): 1.76e-58: 208: 38.82		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		1144063 SYNJ1_RAT (218-639): 1.14e-26: 118: 10.69		UBC_RAT (1-108): 1.27e-29: 127: 90.74