HitPredict

Interactor 1: EPN2 (O95208)
Epsin-2 (EPS-15-interacting protein 2)
Gene: EPN2

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030276 - clathrin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 641 Hs			1 937
+	Rn
		923862 EPN2_RAT (1-641): 8.1e-101: 320: 69.89		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		925867 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		1014011 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Rn
		291389 EPN1_RAT (1-570): 1.18e-64: 224: 39.17		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		926065 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Dm
		1096902 Q8IN05_DROME (3-448): 1.72e-100: 336: 24.18		Q24253_DROME (1-937): 0: 804: 71.75
+	Hs
		1014105 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Dm
		1096905 Q9VD13_DROME (3-599): 2.78e-79: 266: 21.35		Q24253_DROME (1-937): 0: 804: 71.75
+	Hs
		321545 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302148 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		321680 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Rn
		88757 EPN1_RAT (1-570): 1.18e-64: 224: 39.17		D3ZUY8_RAT (11-932): 0: 625: 17.14
+	Hs
		212629 EPN4_HUMAN (3-638): 3.84e-95: 307: 22.15		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Rn
		291387 EPN1_RAT (1-570): 1.18e-64: 224: 39.17		AP2A2_RAT (11-932): 0: 595: 16.50
+	Hs
		302230 EPN1_HUMAN (1-570): 1.42e-61: 216: 39.27		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Rn
		291395 EPN1_RAT (1-570): 1.18e-64: 224: 39.17		Q66HM2_RAT (11-932): 0: 590: 16.38
+	At
		1228257 EPN1_ARATH (2-443): 2.58e-75: 253: 19.04		AP2A1_ARATH (13-934): 0: 556: 16.10
+	Dm
		954828 Q7KU90_DROME (1-640): 8.53e-66: 232: 28.42		AP2A_DROME (11-931): 0: 573: 16.72
+	At
		1195469 EPN1_ARATH (2-443): 2.58e-75: 253: 19.04		AP1G1_ARATH (14-809): 2.91e-173: 527: 16.34
+	At
		1147101 EPN2_ARATH (2-641): 1.33e-53: 199: 21.00		AP2A1_ARATH (13-934): 0: 556: 16.10