HitPredict

Interactor 1: MTMR5 (O95248)
Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1)
Gene: SBF1

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DENN~Ras, PH~Ras, Ras~uDENN
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1868 Hs			1 192
+	Hs
		309467 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		309435 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		309525 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		309470 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		309459 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		309460 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		309429 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		309438 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		925261 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545361 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		1040888 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		892358 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		950979 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		893983 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900451 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		564518 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		925348 DEN4C_HUMAN (22-573): 8.87e-127: 443: 21.03		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		925666 MTMRA_HUMAN (1358-1573): 1.99e-24: 113: 34.38		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71