HitPredict

Interactor 1: I18RA (O95256)
Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
Gene: IL18RAP

Interactor 2: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	21244100, 21832049
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 599 Hs			1 770
+	Hs
		394555 ILRL1_HUMAN (63-573): 1.11e-78: 260: 22.33		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		394931 SIGIR_HUMAN (248-562): 5.08e-55: 194: 22.36		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		394012 FGFR1_HUMAN (44-400): 6.39e-50: 187: 14.64		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		394116 FGFR2_HUMAN (33-400): 6.79e-49: 184: 12.90		A4_HUMAN (19-770): 0: 999: 100.00
+	Mm
		517576 CNTN1_MOUSE (51-449): 4.18e-38: 152: 9.69		A4_MOUSE (1-770): 0: 1016: 96.62
+	Hs
		395129 CNTN4_HUMAN (51-521): 1e-41: 164: 10.04		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		394564 CNTN2_HUMAN (51-481): 1.98e-39: 157: 12.50		A4_HUMAN (19-770): 0: 999: 100.00
+	Mm
		517577 NCAM1_MOUSE (39-290): 7.78e-18: 90: 12.45		A4_MOUSE (1-770): 0: 1016: 96.62
+	Hs
		395963 CNTN3_HUMAN (10-598): 3.25e-20: 97.4: 10.95		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		393980 PGFRB_HUMAN (52-472): 3.21e-13: 75.1: 10.93		A4_HUMAN (19-770): 0: 999: 100.00
+	Dm
		537676 FAS2_DROME (79-353): 1.38e-14: 79.4: 17.48		A4_DROME (13-589): 6.91e-175: 526: 25.52
+	Hs
		296251 CNTN5_HUMAN (51-479): 1.33e-44: 172: 10.56		APLP1_HUMAN (6-194): 9.65e-70: 243: 45.79
+	Hs
		849940 CNTN4_HUMAN (51-521): 1e-41: 164: 10.04		APLP1_HUMAN (6-194): 9.65e-70: 243: 45.79
+	Hs
		849951 CNTN3_HUMAN (10-598): 3.25e-20: 97.4: 10.95		APLP1_HUMAN (6-194): 9.65e-70: 243: 45.79