HitPredict

Interactor 1: GA45G (O95257)
Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2)
Gene: GADD45G

Interactor 2: M3K4 (Q9Y6R4)
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)
Gene: MAP3K4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	33961781, 9827804
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:1900745 - positive regulation of p38MAPK cascade
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 159 Hs			1 1608
+	Hs
		622989 GA45A_HUMAN (1-159): 1.37e-79: 234: 54.49		M3K4_HUMAN (1-1608): 0: 2122: 100.00
+	Hs
		258882 GA45B_HUMAN (1-159): 1.48e-77: 229: 54.94		M3K4_HUMAN (1-1608): 0: 2122: 100.00