HitPredict

Interactor 1: TNKS1 (O95271)
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)
Gene: TNKS

Interactor 2: CE170 (Q5SW79)
Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)
Gene: CEP170

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1327 Hs			1 1584
+	Hs
		310053 TNKS1_HUMAN (1-1327): 0: 972: 100.00		MDC1_HUMAN (29-1563): 8.72e-84: 307: 10.03
+	Hs
		310076 TNKS1_HUMAN (1-1327): 0: 972: 100.00		C170L_HUMAN (1275-1584): 2.13e-29: 121: 93.23
+	Hs
		1131844 TNKS2_HUMAN (39-198): 1.68e-13: 77.6: 9.38		CE170_HUMAN (1-1584): 0: 654: 100.00
+	Hs
		166985 ANR28_HUMAN (39-924): 1.84e-160: 511: 22.33		TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68
+	Hs
		166913 ANR28_HUMAN (39-924): 1.84e-160: 511: 22.33		ANK2_HUMAN (318-1298): 5e-14: 80.2: 13.65
+	Hs
		556716 ANK1_HUMAN (7-703): 5.93e-127: 435: 21.42		TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68
+	Hs
		1021422 ANK3_HUMAN (7-703): 2.82e-131: 450: 22.11		MICA3_HUMAN (662-1403): 1.36e-13: 78.7: 12.99
+	Mm
		103608 ANK3_MOUSE (655-1264): 1.26e-109: 384: 19.25		ANK2_MOUSE (123-1379): 8.94e-11: 69.4: 13.83
+	Hs
		1056981 TNKS2_HUMAN (39-198): 1.68e-13: 77.6: 9.38		MDC1_HUMAN (29-1563): 8.72e-84: 307: 10.03
+	Hs
		807690 ANK2_HUMAN (42-386): 1.1e-50: 200: 16.58		MAP1B_HUMAN (175-1557): 2.54e-45: 183: 9.56
+	Mm
		57333 A2AM57_MOUSE (107-393): 7.61e-36: 150: 23.10		A2ARP8_MOUSE (91-1569): 1.96e-49: 196: 9.09
+	Mm
		57442 A2AM57_MOUSE (107-393): 7.61e-36: 150: 23.10		MAP1A_MOUSE (91-1569): 1.8e-49: 196: 9.09
+	Mm
		57341 A2AM57_MOUSE (107-393): 7.61e-36: 150: 23.10		E9QMK2_MOUSE (661-1584): 5.44e-32: 138: 10.69
+	Dm
		1182373 Q7KU92_DROME (864-1265): 1.94e-44: 179: 10.26		Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84
+	Dm
		1361443 Q9VAU5_DROME (823-1266): 9.8e-39: 160: 13.85		Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84
+	Dm
		1362722 ANKHM_DROME (901-1105): 4.27e-19: 96.5: 14.47		Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84