HitPredict

Interactor 1: TNKS1 (O95271)
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)
Gene: TNKS

Interactor 2: TB182 (Q9C0C2)
182 kDa tankyrase-1-binding protein
Gene: TNKS1BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	11854288, 12080061
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1327 Hs			1 1729
+	Mm
		103594 ANK3_MOUSE (655-1264): 1.26e-109: 384: 19.25		TB182_MOUSE (1-1721): 0: 1127: 69.10
+	Hs
		1318953 ANFY1_HUMAN (41-654): 2.09e-64: 242: 14.41		TB182_HUMAN (1-1721): 0: 1143: 100.00
+	Hs
		257696 ANR17_HUMAN (862-1203): 6.2e-38: 158: 14.70		TB182_HUMAN (1-1721): 0: 1143: 100.00
+	Hs
		1318943 TNKS2_HUMAN (39-198): 1.68e-13: 77.6: 9.38		TB182_HUMAN (1-1721): 0: 1143: 100.00
+	Hs
		310053 TNKS1_HUMAN (1-1327): 0: 972: 100.00		MDC1_HUMAN (52-890): 1.24e-12: 75.5: 8.70
+	Hs
		1021422 ANK3_HUMAN (7-703): 2.82e-131: 450: 22.11		MICA3_HUMAN (6-582): 6.94e-11: 69.7: 9.93
+	Hs
		556706 ANK1_HUMAN (7-703): 5.93e-127: 435: 21.42		OBSCN_HUMAN (53-664): 1.02e-14: 82.6: 16.67
+	Hs
		965118 ANK2_HUMAN (42-386): 1.1e-50: 200: 16.58		OBSCN_HUMAN (53-664): 1.02e-14: 82.6: 16.67
+	Dm
		1182373 Q7KU92_DROME (864-1265): 1.94e-44: 179: 10.26		Q9VLS7_DROME (10-796): 2.12e-14: 81.6: 11.18
+	Dm
		1361443 Q9VAU5_DROME (823-1266): 9.8e-39: 160: 13.85		Q9VLS7_DROME (10-796): 2.12e-14: 81.6: 11.18
+	Hs
		274704 TRPA1_HUMAN (866-1209): 5.56e-34: 144: 11.62		HUWE1_HUMAN (235-607): 2.45e-15: 84.5: 16.79
+	Mm
		57333 A2AM57_MOUSE (107-393): 7.61e-36: 150: 23.10		A2ARP8_MOUSE (5-879): 2.04e-13: 78.2: 11.59
+	Mm
		57442 A2AM57_MOUSE (107-393): 7.61e-36: 150: 23.10		MAP1A_MOUSE (7-764): 8.51e-12: 73.1: 11.57
+	Hs
		257652 ANKH1_HUMAN (862-1203): 2.35e-34: 146: 14.12		ANR17_HUMAN (1-411): 1.22e-09: 65.8: 12.56
+	Dm
		1362722 ANKHM_DROME (901-1105): 4.27e-19: 96.5: 14.47		Q9VLS7_DROME (10-796): 2.12e-14: 81.6: 11.18
+	Hs
		1056981 TNKS2_HUMAN (39-198): 1.68e-13: 77.6: 9.38		MDC1_HUMAN (52-890): 1.24e-12: 75.5: 8.70