Interactor 1: TNKS1 (O95271)
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)
Gene: TNKS

Interactor 2: HIF1N (Q9NWT6)
Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)
Gene: HIF1AN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 28514442, 26972000, 33961781, 17003112, 24145445, 21251231
Identification Methods affinity chromatography technology, hydroxylase assay, anti tag coimmunoprecipitation, enzymatic study
Interaction Type physical association, association, hydroxylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Cupin_8
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 1327
Hs

1 349
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Last updated: 15 Jul 2024